NRNB: Enrichment Map

Enrichment Map

Enrichment Map is a Cytoscape app for functional enrichment visualization. Enrichment results have to be generated outside Enrichment Map, using any of the available methods. Gene-sets, such as pathways and Gene Ontology terms, are organized into a network (i.e. the "enrichment map"). In this way, mutually overlapping gene-sets cluster together, making interpretation easier. Enrichment Map also enables the comparison of two different enrichment results in the same map.

Documentation

Developer Resources

Code Repository

How to Cite

Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation. Merico et al., PLoS One 2010.

Image Gallery

Hierarchical visualization of enrichment results for estrogen treatment of breast cancer cells.
Enrichment map for estrogen treatment of breast cancer cells at 24 hours of culture.
Zoom in of the microtubule cytoskeleton cluster in the 24 hours estrogen treatment enrichment map.

Enrichment map for estrogen treatment of breast cancer cells at 12 and 24 hours of culture.
Heat-maps displaying gene-set expression patterns in the estrogen treatment experiment.
Enrichment map for early-onset colon cancer and overlap with known disease genes.