NeXO is a gene ontology inferred directly from large-scale molecular networks. A gene ontology provides structured knowledge about the cellular components, processes, and functions encoded by genes. While most ontologies – including the highly successful Gene Ontology Database (GO) – are constructed through manual expert curation, NeXO is a data-driven gene ontology inferred directly from ‘omics data. NeXO (The Network Extracted Ontology) uses a principled computational approach which integrates evidence from hundreds of thousands of individual gene and protein interactions to construct a complete hierarchy of cellular components and processes. This data-derived ontology aligns with known biological machinery in the GO Database and also uncovers many new structures.

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NeXO Web Overview

NeXO Web overview. Users can browse NeXO DAG and raw interactions from web browsers.

NeXO Raw Interaction View

Raw interaction view. Source interaction data for each NeXO term is visualized by Cytoscape.js.

NeXO Search

NeXO terms can be searched by keywords, term ID, or gene names.

NeXO Term Enrichment

NeXO term enrichment analysis is a built-in feature in NeXO Web

GO Viewer

Gene Ontology Viewer. Tree-version of Gene Ontology can be visualized by NeXO Web.